Moderna Therapeutics Inc’s experimental COVID-19 vaccine, the first to be tested in the United States, produced protective antibodies in a small group of healthy volunteers, Reuters reported, citing very early data released by the biotech company on Monday.
Moderna Therapeutics’ co-founder and director is American entrepreneur of Armenian descent Noubar Afeyan.
The data comes from eight people who took part in a 45-subject safety trial that kicked off in March.
Overall, the study showed the vaccine was safe and all study participants produced antibodies against the virus.
An analysis of the response in the eight individuals showed that those who received a 100 microgram dose and people who received a 25 microgram dose had levels of protective antibodies to fend of the virus that exceeded those found in the blood of people who recovered from COVID-19, the illness caused by the coronavirus.
“These are significant findings but it is a Phase 1 clinical trial that only included eight people. It was designed for safety, not for efficacy,” said Dr Amesh Adalja, in infectious disease expert at the Johns Hopkins Center for Health Security who was not involved in the study.
The very early data offers a glimmer of hope for a vaccine among the most advanced in development.
Adalja said many glitches can occur between now and the time this vaccine is tested for efficacy in thousands of people. “What we do see is encouraging,” he said.
Moderna said the vaccine appeared to show a dose response, meaning that people who the 100 mcg dose produced more antibodies than people who got the lower dose.
In the Phase II, or midstage, trial designed to further test effectiveness and find the optimal dose, Moderna said it will drop plans to test a 250 mcg dose and test a 50 mcg dose instead.
Moderna said it expects to start a larger late-stage, or Phase III, trial in July.
https://www.panorama.am/en/news/2020/05/19/coronavirus-vaccine-trial-Noubar-Afeyan/2293905
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